Leber Hereditary Optic Neuropathy - EyeWiki

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Leber Hereditary Optic Neuropathy - EyeWiki

Leber Hereditary Optic Neuropathy (LHON) is the most common inherited mitochondrial disorder and typically affects young males. It typically begins as a unilateral progressive optic neuropathy with sequential involvement of the fellow eye months to years later. Treatment options are limited, but include the use of antioxidant supplements.

Primary Mitochondrial Disorders Overview - GeneReviews - NCBI …

Jun 08, 2000 Each human cell contains thousands of copies of mtDNA. At birth these are usually all identical ().By contrast, individuals with mitochondrial disorders resulting from mtDNA pathogenic variants may harbor a mixture of mutated and wild type mtDNA within each cell (heteroplasmy) [Holt et al 1988, Holt et al 1990].Single-cell studies have shown that the …

Optic nerve - Wikipedia

In neuroanatomy, the optic nerve, also known as the second cranial nerve, cranial nerve II, or simply CN II, is a paired cranial nerve that transmits visual information from the retina to the brain.In humans, the optic nerve is derived from optic stalks during the seventh week of development and is composed of retinal ganglion cell axons and glial cells; it extends from the …

Leber Hereditary Optic Neuropathy - GeneReviews - NCBI Bookshelf

Oct 26, 2000 Leber hereditary optic neuropathy (LHON) typically presents in young adults as bilateral, painless, subacute visual failure. The peak age of onset in LHON is in the second and third decades of life, with 90% of those who lose their vision doing so before age 50 years. Very rarely, individuals first manifest LHON in the seventh and eighth decades of life. Males are four …

Leber's hereditary optic neuropathy - Wikipedia

Leber's hereditary optic neuropathy (LHON) is a mitochondrially inherited (transmitted from mother to offspring) degeneration of retinal ganglion cells (RGCs) and their axons that leads to an acute or subacute loss of central vision; it predominantly affects young adult males. LHON is transmitted only through the mother, as it is primarily due to mutations in the mitochondrial …


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